Treatments involving polynucleotides have gained popularity in aesthetic medicine, particularly for areas like the face, neck, hands, knees, and elbows. These biocompatible compounds aim to rejuvenate and restore the skin's natural vitality by promoting collagen production and enhancing hydration. In the face, polynucleotide injections can reduce fine lines and improve skin texture, while on the neck, they help combat sagging and dryness. For hands, these treatments provide a youthful appearance, addressing age spots and crepey skin. Similarly, when applied to knees and elbows, polynucleotides assist in reducing signs of wear and tear, providing hydration and elasticity to often neglected areas. The versatility of polynucleotide treatments makes them an excellent option for comprehensive skin rejuvenation across various body parts.